Follow the official guide to set up your Cloudinary account and the plugin. You do not need to "register" the CND with other optimization or cache plugins — it will just work.
-- Assume missing options are off, empty, or left to default.-
- [General settings] Media Library Sync Settings: --
- - [x] Sync method: Auto sync
-
- [General settings] Cloudinary folder path:
-  To keep things orderly, use a folder name that relates to your site.
- [General settings] Storage: --
- - [x] Cloudinary and WordPress
-
- [Image settings] Image optimization: --
- - [x] Optimize images on my site.
-- - [x] Image format: Auto
-- - [x] Image quality: Auto
-
- [Lazy loading] Lazy loading: --
- - [x] Enable lazy loading
-- - [x] Lazy loading threshold: 100px
-- - [x] Pre-loader color: You decide!
-- - [x] Pre-loader animation: You decide!
-- - [x] Placeholder generation type: You decide!
-- - [x] DPR settings: Auto (2x)
-
- [Responsive images] Breakpoints: --
-- - [ ] Enable responsive images (OFF - this increases usage)
-